منابع مشابه
Glycosaminoglycans and Proteoglycans
In this editorial to MDPI Pharmaceuticals special issue "Glycosaminoglycans and Proteoglycans" we describe in outline the common structural features of glycosaminoglycans and the characteristics of proteoglycans, including the intracellular proteoglycan, serglycin, cell-surface proteoglycans, like syndecans and glypicans, and the extracellular matrix proteoglycans, like aggrecan, perlecan, and ...
متن کاملGlycosaminoglycans and proteoglycans: overlooked entities?
BACKGROUND By virtue of their high net negative charge, glycosaminoglycans and proteoglycans play pivotal roles in biologic processes such as cell-cell and cell-matrix interactions, sequestration of growth factors, activation of chemokines and cytokines, and permselectivity of basement membranes. METHODS The present article reviews the putative roles of glycosaminoglycans and proteoglycans in...
متن کامل3.05 Biosynthesis of Glycosaminoglycans and Proteoglycans
Sulfated glycosaminoglycans (GAGs) are linear polysaccharides consisting of repeating disaccharide units composed of N-acetylhexosamine and uronic acid, and exist as proteoglycans (PGs) by attaching to specific serine residues in the core protein. PGs are ubiquitously distributed on the cell surface and in the extracellular matrix and play critical roles in a variety of physiological phenomena ...
متن کاملRoles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis
A wound is a type of injury that damages living tissues. In this review, we will be referring mainly to healing responses in the organs including skin and the lungs. Fibrosis is a process of dysregulated extracellular matrix (ECM) production that leads to a dense and functionally abnormal connective tissue compartment (dermis). In tissues such as the skin, the repair of the dermis after woundin...
متن کاملMetabolism of proteoglycans and glycosaminoglycans in cultivated fibroblasts.
s of Communications 567th Meeting of the Biochemical Society University of Durham 6 and 7 January 1977 SECRETIONAL ASPECTS OF GLYCOCONJUGATES: a Colloquium organized by P. W. Kent (Durham) Metabolism of Proteoglycans and Glycosaminoglycans in Cultivated Fibroblasts
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ژورنال
عنوان ژورنال: Pharmaceuticals
سال: 2018
ISSN: 1424-8247
DOI: 10.3390/ph11010027